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KMID : 0350519960490010407
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Journal of Catholic Medical College
1996 Volume.49 No. 1 p.407 ~ p.414
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Effect of the Local Doxorubicin Injection on the Extraocular Muscle
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Abstract
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Local doxorubicin injections have been clinically used to treat blepharospasm and hemifacial spasm nonsurgically for a long time. Doxorubicin is an effective myotoxic agent for the removal of orbicularis oculi muscle in the eyelid after local
injection.
To investigate the chemomyectomy effect of doxorubicin on extraocular muscle, we injected 0.05ml doxorubicin into right superior rectus muscle for the experimental group and 0.05ml balanced salt solution into left superior rectus muscle for the
control
group of 12 rabbits, under general anesthesia. Rabbits were sacrificed and the gross and histologic examinations were done at 1, 2, 4 and 8 weeks after the injection.
@ES The results were as follows;
@EN 1. In gross examination, thickness of muscle mass at injection site was decreased with the lapse of time in the experimental group while there was no osservable muscle changes and no interval changes in the control group. theree was no
conjunctival
adhesion or symblepharon and scleral necrosis was not found.
2. In microscopic examination, the number of muscle fiber was decreased and muscle fragmentation and necrosis were found. Necrotic muscle mass was displaced by interstitial connective tissue and the degree of muscle loss was increased with the
lapse of
time in the experimental group. Where as muscle fibers were normally visible and no interstitial connective tissue was found, which were not changed with the lapse of time in the control group.
These results suggested that doxorubicin was also an effective myotoxin to extraocular muscle, that it was highly selective to muscle cells and easy to localized within a given given muscle and its effect was continuous, so it could be used for
nonsurgical treatment of chronic paralytic and restricted form of strabismus.
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